|
KMID : 0382420030290020016
|
|
Korean Journal of Environmental Health Society
2003 Volume.29 No. 2 p.16 ~ p.22
|
|
|
Effects of Butyl Benzyl Phthalate on Dams and F1 during Lactation Period of Rats
|
|
Kim Pan-Gyi
Yang Yool-Hee
|
|
|
Abstract
|
|
|
|
BBP (Butyl benzyl phthalate), a widely used plasticizer, can enter the food and environment as consequence of its manufacture, use, and disposal. BBP was found to be developmental and teratogenic or endocrine disrupting chemical in rats. The effects of BBP were investigated in female rats (P) and second generation (F1) via lactations. Sprague-Dawley were given BBP by oral administration at 0,5, 10, 100, 1000 mg/kg on day 0 to 21 of lactation period. The results were as follows; At maternal findings, there were some significant changes (p<0.05) in relative organ weight, especially liver and ute겨s weight by BBP administration. In estrous cycle, high treated group was inclined to be proestrus or estrus compared to control group. BBP indues estrous cycle earlier than the control group. At fetal findings, there were some significant changes in relative liver and spleen weight, especially 100, 1000 mg/kg administered groups. The relative weight of ventral prostate was decreased, so it was represent to dose-response tendency. Parent rats (P) were detected monobenzyl phthalate (MBeP) 3.21-5.81 ㎍/ml in 100, 1000 mg/kg dose groups. MBeP of male and female fetuses (FI) were detected at the level of 1.21-2.63 Ilg/ml of serum. Male serum concentration of MBeP was higher than the females’. Estrogen receptor a expression by BBP and bisphenol A in utems and testis of FI were studied. The ERa expression were increased in F1 male testis and female uterus. F1 male showed distint ERa expression, especially in the combined exposrue. Synergistic ERa expression was found by combined treatment group of BBP and bisphenol A. From the above results, it could be concluded that the effects of dams and FI by BBP administration during lactation period were estrogenic. and BBP can transfer to F1 via lactation, and make estrogenic at F1 reproductive organs.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|